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No certain dose adjustment proposed when tofacitinib coadministered with potent CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with equally average CYP3A4 and strong CYP2C19 inhibitors .Renal Impairment: Modafinil ought to be utilized with caution in clients with severe renal impairment. Nevertheless, no recommendations for renal d